Dallas, Texas 05/28/2014 (FINANCIALSTRENDS) – BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) yesterday announced positive results from its OPuS-1 study for the prophylactic treatment of hereditary angioedema which is a Phase IIa trial for BioCryst’s pipeline product BCX4161, administered orally. The proof of concept study met the primary efficacy endpoint and many secondary endpoints. The trial evaluated orally administered BCX4161 at a dose of 400 mg, three times a day for 28 days in hereditary angioedema patients with a high attack frequency. OPuS-1 was a two period cross over, placebo controlled, randomized clinical trial.
The primary goal for the trial was to assess the BCX4161’s clinical efficacy in reducing the frequency of attacks in hereditary angioedema patients while evaluating the safety and tolerability profile of the candidate.
Encouraging Study Results
BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX)’s OPuS-1 study evaluated the drug efficacy on 24 patients whereby the treatment with BCX4161 suggested a statistically significant mean attach rate reduction as compared to placebo. The company also reported that the oral dose of drug was safe and well tolerated. The company reported 98% patient dosing compliance. An adverse event profile was also similar to that of placebo. In addition, three patients were “attack-free” during the drug treatment as compared to none during the placebo period.
BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) also measured disease activity and quality of life using AAS28 (Angioedema Activity Score) and AeQoL (Angioedema Quality of Life questionnaire). AAS28 score was reported at 21.4 v/s 28.8, p=0.022 and AeQoL score improvement of 8.4 v/s 0.5 units from baseline, p=0.004, respectively for BCX4161 v/s placebo.
The Principal Investigator of OPuS-1 study, Marcus Maurer regarded the OPuS-1 as a “milestone” study as the proof of concept suggests prophylaxis to reduce attacks in patients living with hereditary angioedema.
Yesterday, the stock closed at $9.99, gaining nearly 11% from its previous close. The stock traded with significant volume of 7.84 million shares against its 30 day average volume of 680.37 K shares.
This report is for information purposes only, and is neither a solicitation or recommendation to buy nor an offer to sell securities. Financials Trend is not-a-registered-investment-advisor. Financials Trend is not a broker-dealer. Information, opinions and analysis contained herein are based on sources believed to be reliable, but no representation, expressed or implied, is made as to its accuracy, completeness or correctness. The opinions contained herein reflect our current judgment and are subject to change without notice. Financials Trend accepts no liability for any losses arising from an investor's reliance on the use of this material. Financials Trend sometimes gets compensated up to one hundred and fifty thousand dollars per month for featuring particular stocks. See site disclaimer for complete compensation. Financials Trend and its affiliates or officers currently hold no shares of these stocks. Financials Trend and its affiliates or officers will purchase and sell shares of common stock of these stocks, in the open market at any time without notice. Financials Trend will not update its purchases and sales of these stocks in any future postings on Financials Trend's websites. Certain information included herein is forward-looking within the context of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements concerning manufacturing, marketing, growth, and expansion. The words "may", "would," "will," "expect," "estimate," "anticipate," "believe," "intend," " project," and similar expressions and variations thereof are intended to identify for ward-looking statements. Such forward- looking information involves important risks and uncertainties that could affect actual results and cause them to differ materially from expectations expressed herein. *Financials Trend does not set price targets on securities. Never invest into a stock discussed on this web site or in this email alert unless you can afford to lose your entire investment.